FOCUS ON FIVE STORY LINES

1 Tiebreaker in the East Cowboys at Eagles

Philadelphia has a chance to sweep the season series and take a one-game lead in the NFC East with a victory, but Dallas has some extra rest after playing a Thursday night game.

2 West Coast wipeout? 49ers at Seahawks

San Francisco is in free fall, and this "rematch" of last year's NFC title game has all the makings of a rout by Seattle. Does that seal Jim Harbaugh's fate?

3 Giving Peyton a rest Broncos at Chargers

Denver has been winning behind the running attack, led by C.J. Anderson (pictured), which takes pressure off Peyton Manning. The Ponies have a pretty good run defense as well. San Diego is eager to make a statement, or will it be a last testament?

4 Will lightning strike twice? Dolphins at Patriots

New England can clinch the AFC East with a victory, but the Dolphins are a desperate team that has already handed the Pats a loss.

5 Johnny Football's big chance Bengals at Browns

Cleveland has rookie Johnny Manziel starting in its last-gasp chance to get back in the playoff hunt. The fans are ready, and members of the Cincy defense better be as well … to make the "money" sign when they sack him.