Drug for peanut allergy may go mainstream

Chicago Tribune
October 12, 2019 at 3:00PM
Eleven-year-old Mathieu Bui of Chicago drinks 90 milliliters of walnut milk and cashew milk as part of a treatment to eliminate his allergies at Kenilworth Medical Associates on Wednesday, Sept. 18, 2019 in Kenilworth, Ill. Bui has allergies to five tree nuts, including peanuts, walnuts, pecans, cashews and pistachios. In March of 2018 he began undergoing treatment to be desensitized to these nuts under the medical care of Dr. Paul Detjen. He is already able to eat peanuts and is expected to be
Eleven-year-old Mathieu Bui of Chicago drinks 90 milliliters of walnut milk and cashew milk as part of a treatment to eliminate his allergies at Kenilworth Medical Associates on Wednesday, Sept. 18, 2019 in Kenilworth, Ill. Bui has allergies to five tree nuts, including peanuts, walnuts, pecans, cashews and pistachios. In March of 2018 he began undergoing treatment to be desensitized to these nuts under the medical care of Dr. Paul Detjen. He is already able to eat peanuts and is expected to be free of his allergies to all five of these nuts by the end of 2019. (Tns - Tns/The Minnesota Star Tribune)

Chicago – Lauren Tilmont didn't believe it when her doctor said he had a treatment that might allow her to eat peanuts, despite a lifelong allergy.

"The first thing I told him was, 'You're crazy,' " said Tilmont, 25. She had been told nearly her whole life that peanuts could kill her. But she decided to give her doctor's plan a try.

He gave her a tiny bit of peanut protein and monitored her in his office for reactions. Gradually, he stepped up the amount she ate, over about 10 months. Today, peanut butter upsets her stomach, but she can snack on Snickers bars and munch on peanut M&Ms.

Tilmont called the treatment the most difficult thing she's ever done, but "it has empowered me," she said.

It's a somewhat controversial treatment that hasn't been widely available. But a similar approach may be about to go mainstream. A U.S. Food and Drug Administration expert panel recommended approval of the first drug designed to reduce allergic reactions in children with peanut allergies. The recommendation makes it likely that the drug, Palforzia, made by Aimmune Therapeutics, will get FDA approval. The FDA is expected to decide by January.

The drug is not meant as a cure. Rather, it's designed to decrease the amount and severity of allergic reactions after accidental exposure to peanuts. But many families dealing with peanut allergies said it could be life-changing, potentially freeing them from the worry that their kids could go into anaphylaxis or even die because of a simple mistake.

Doctors warn that reactions may still happen, including at home where it will be up to parents to take action.

"We are glad this is coming to the forefront, but it is not for all patients," said Dr. Paul Detjen, who treated Tilmont.

Palforzia delivers a daily dose of peanut protein that's increased over time, for children ages 4 to 17. After about a year of taking the drug, about two-thirds of children in a clinical trial were able to eat the equivalent of at least two peanuts without an allergic reaction, said a study published in the New England Journal of Medicine.

Eleven-year-old Mathieu Bui of Chicago drinks 90 milliliters of walnut milk and cashew milk as part of a treatment to eliminate his allergies at Kenilworth Medical Associates on Wednesday, Sept. 18, 2019 in Kenilworth, Ill. Bui has allergies to five tree nuts, including peanuts, walnuts, pecans, cashews and pistachios. In March of 2018 he began undergoing treatment to be desensitized to these nuts under the medical care of Dr. Paul Detjen. He is already able to eat peanuts and is expected to be
Mathieu Bui, 11, drank walnut and cashew milk in an effort to eliminate his allergies. (The Minnesota Star Tribune)
about the writer

about the writer

Lisa Schencker