Donald Trump became the presumptive Republican presidential nominee last week when his win in Indiana's primary chased Sen. Ted Cruz and Gov. John Kasich out of the race. On the Democratic side, Sen. Bernie Sanders carried Indiana, but Hillary Clinton has a substantial delegate lead. A closer look at the likely fall matchup:

Donald Trump is polling at 41 percent in a general-election matchup with Clinton, according to the latest CNN poll.

"I call her crooked Hillary. She's crooked. She'll be a horrible president. … She will not be a good president. She doesn't have the strength, she doesn't have the stamina."

Once supported abortion rights; no longer does. Doesn't support limits on gun ownership. Says the Affordable Care Act should be repealed. Promises to lower middle-class and low-income taxes.

His campaign website says he "advocates for conservative causes," but his previous support for Democratic candidates and his positions on issues such as entitlement reform and trade make him a populist. Will he say or do something so outrageous that voters abandon him?

His New York roots are on full display in this format. He's pugnacious, dismissive and quick with snide and sometimes funny asides. He's usually impulsive, not scripted.

57 percent of Americans view him unfavorably.

Dr. Ben Carson is running the search but says he's not interested — just what Dick Cheney said in 2000 when he led George W. Bush's hunt. Gov. Chris Christie, ex-Speaker Newt Gingrich top many lists.

He has won in 28 states and territories, amassing 1,019 pledged delegates. A total of 1,237 delegates will secure the nomination.

He's an outsider in a year when many voters are yearning for one. But he's been all over the map on issues, sometimes displays a startling lack of knowledge, and has a penchant for reckless pronouncements.

He'll be 70 on June 14. Born in Queens, N.Y., he graduated in 1968 from the Wharton School of the University of Pennsylvania. He's been married three times and has five children.

Chairman, president of the Trump Organization, host of "The Apprentice," founder of Trump Entertainment Resorts.

Manages Central Park's Wollman Rink and Carousel.

Hillary Clinton is polling at 54 percent in a general-election matchup with Trump, according to the latest CNN poll.

"I don't think we can take a risk on a loose cannon like Donald Trump running our country. … He's [been running a] very negative, aggressive, bullying campaign."

Supports abortion rights. Lobbied for tougher gun laws. Supports the Affordable Care Act. Says the wealthy should pay more in taxes; middle class should pay less.

She can "take on tough fights and get things done," her campaign website says. She's reliably liberal on social and economic issues but is viewed as more of a hawk on foreign policy than President Obama.

How will the investigation into her use of a private e-mail server end?

She sometimes answers questions like an attorney, giving detailed but cautious responses. She's assertive and lets her annoyance show — especially when she's interrupted.

52 percent of Americans view her unfavorably.

Much of the buzz has centered on Virginia Sen. Tim Kaine, a Spanish-speaking former governor. Choosing Sen. Elizabeth Warren, a favorite of progressives, would make history. Probably not: Sen. Bernie Sanders.

She has won in 26 states and territories, amassing 1,706 pledged delegates (including 4 in Guam on Saturday) of the 2,383 needed.

Her broad experience, toughness and seriousness are undeniable. But she hasn't been able to shake perceptions that she's not quite trustworthy, and Clinton fatigue is a factor after her decades in politics.

She'll be 69 on Oct. 26. Born in Chicago, she graduated from Wellesley College and Yale Law School. She's been married to former President Bill Clinton since 1975 and has a daughter, Chelsea.

Former secretary of state, U.S. senator from New York, first lady of the U.S., first lady of Arkansas, lawyer.

Always travels with red pepper flakes and Tabasco hot sauce.