There have been plenty of theories thrown around this off-season attempting to identify the reasons behind Denard Span's 2010 statistical regression:
He's been hitting with two-strikes more frequently.
The transition to natural grass from turf has shaved points off his batting average.
He played too much and needed more rest.
While all of those were factors to some extent, more tangibly, Twins Hitting Coach Joe Vavra recently acknowledged a slight flaw in his mechanics last year that he believed contributed to his offensive woes.
In conversations with Vavra on the subject of Span, 1500ESPN's Phil Mackey wrote that Vavra attributed the increase in grounders on the center fielder not keeping his head as still as he had in previous season:
Reviewing video footage of Span's swing dating back to 2008, there is ample visual evidence of additional bouncing this season. Comparative to his two prior years, Span's 2010 mechanics demonstrate a wellspring of pre-swing movement:



Whereas in his first two seasons with the Twins Span remained relatively still prior to moving his front foot forward, he has since implemented a bit of a squat. What you will also notice is that Span's top half loads more, pulling his front shoulder inward towards the plate as he brings the bat back. Either of these variations could be causing his eye level to change planes as Vavra mentioned. And because of that, it would make complete sense that he would be striking the top half or lower half of the ball more frequently.