SANTA CLARA, Calif. — When quarterback Jimmy Garoppolo and All-Pro tight end George Kittle went down with significant injuries early in the week, the already-depleted San Francisco 49ers knew they were in for a tough task on a short week.
The problems only got bigger when a positive coronavirus test for receiver Kendrick Bourne sidelined three more key players.
The end result, a 34-17 loss to the Green Bay Packers on Thursday night, was hardly surprising even if it was still disappointing.
"We knew it was going to be a challenge," coach Kyle Shanahan said. "We knew at the start of the week it would be a challenge. Losing those three guys yesterday would be a bigger challenge. I still thought we could have a game. ... I know we could have done better."
Instead, the Niners (4-5) ended up being little match for a Green Bay team they dominated twice last season, outscoring the Packers 74-28 combined in the regular season and the NFC championship game.
But the 49ers were a shell of that roster in the rematch with Garoppolo (ankle), Kittle (foot), NFC title game star running back Raheem Mostert (ankle), receiver Deebo Samuel (hamstring) and key defenders Nick Bosa (knee), Dee Ford (back) and Richard Sherman (calf) all sidelined by injuries.
That was followed by Bourne's positive test that came back Wednesday and led to receiver Brandon Aiyuk and left tackle Trent Williams being sidelined as "high risk" close contacts.
That made the Niners the first team since the 1970 merger to play a game without its starting QB and six of its top seven players in yards from scrimmage, outside of the 1987 replacement player games.