The Twins will open the 2023 season on the road in Kansas City on March 30.
The team's schedule for next season was released on Wednesday, and major league teams will now play at least one series against each other under the new format.
After playing the Royals and Miami on the road to start the season, the Twins will have their home opener against Houston on Thursday, April 6, as part of a six-game homestand that will include the White Sox.
The Twins and Brewers will play at Target Field on June 13-14 and in Milwaukee on Aug. 22-23.
Other National League teams playing at Target Field in 2023 will be Washington, San Diego, the Cubs, San Francisco, Arizona, Pittsburgh and the New York Mets.
Home night games Monday-Thursday will continue to start at 6:40 p.m.
The Twins will play the other American League Central teams 13 times each after facing them 19 times apiece in 2022.
The season ends Oct. 1 in Colorado.