Matt Dumba shook up the action, but the Sharks broke open the game.
That's the gist of a 50-second span that flipped a potential tie into a deeper deficit, one the Wild couldn't shake en route to a 4-1 loss on Tuesday night in front of 15,367 at Xcel Energy Center after returning home from a successful road trip.
"We didn't have enough in this hockey game, and they did," Wild coach Dean Evason said. "We need more from a lot of different players."
Down 2-1 but playing better in the second period, the Wild had a chance at the equalizer on the power play.
After Dumba crushed San Jose's Alexander Barabanov, catching Barabanov with his backside while Barabanov had his head down along the boards, Dumba was immediately accosted by Sharks veteran Tomas Hertl.
"It's a clean, Rob Blake-esq hit," Wild winger Marcus Foligno said.
Only Hertl was penalized on the play, for roughing, but the ensuing power play was short-lived. Center Joel Eriksson Ek, who scored earlier in the period, negated it with a tripping penalty after only 40 seconds.
And 10 seconds after that, while play was at 4-on-4, Erik Karlsson put San Jose up 3-1 on a booming slapshot that sailed by Wild goalie Cam Talbot at 9 minutes, 32 seconds.