Royce Lewis homered for the third consecutive game. Pablo López pitched six innings. Michael A. Taylor probably saved a run with a diving catch and added a homer.
It was one of those games where the Twins didn't play poorly. Just none of it was good enough. Lewis drilled a solo homer, but he flew out with the bases loaded in the first inning. López allowed three runs when he wasn't at his sharpest.
The Cleveland Guardians lost their starting pitcher, Gavin Williams, to a knee injury after the first inning, but the Twins failed to capitalize when they had runners in scoring position against the bullpen during their 4-2 loss Tuesday night at Target Field.
The Twins' lead in the American League Central Division slipped to six games over the Guardians.
"It does come down to, sometimes, just one or two swings and putting them on the ball at the right time," Twins manager Rocco Baldelli said. "We didn't do that today."
Lewis received a standing ovation from a portion of the 23,433 fans when he came up to the plate with the bases loaded in the first inning. He had hit grand slams in back-to-back games, the first rookie in major league history to accomplish the feat, and the Twins set the stage for another dramatic moment through a walk, an error and a hit batsman.
In a seven-pitch at-bat, Lewis finally looked human when he ended the inning with a flyout in shallow right field. Twins hitters went 0-for-9 with runners in scoring position.
"You think he's going to hit a grand slam," Baldelli said. "Why would we not think that?"