Manufacturers dominated the Star Tribune 100 list of public companies, comprising a third of the state's heftiest revenue generators in 2015.
3M and General Mills again graced the top 10 slots, as they have for 25 years of the Star Tribune 100.
And despite disparate headwinds, other Minnesota-based manufacturers ranking in this year's top 25 included Ecolab, Hormel, Valspar, Polaris, Pentair, Medtronic and St. Jude.
Combined, manufacturers produced $80 billion in 2015 sales, down 3 percent. Profits plunged 56 percent to $5.3 billion as Minnesota's multinational producers wrestled mightily with unfavorable currency exchange rates, depressed oil markets, shriveling economies in China and Canada, a cruel bird flu and shifting tastes in food and consumer electronics.
To compare, retailers, restaurants, health insurers and other nonmanufacturing firms increased sales 7.5 percent, while their profits dropped 3 percent.
Recent economic reports from the Creighton University and Enterprise Minnesota showed that Minnesota's industrial firms also struggled with a tight labor market and near-zero unemployment rates. They also suffered from downturns in ore mining and agriculture equipment markets.
In the end, 2015 product orders, delivery lead times, inventories and employment slowed.
Reports from the Institute of Supply Management (ISM) show that Minnesota manufacturers are not alone in their struggles. And while manufacturing comprises only 12 percent of the U.S. economy, according to ISM, its performance is often a harbinger of future growth or contraction.