Who wins — Penn State or Auburn? Find out in Randy Johnson's weekly Big Ten picks

The third full week of the season features five Big Ten teams facing Power Five opponents Saturday, and Penn State, Michigan State and Nebraska have the biggest challenges. (Note: The Gophers-Colorado prediction will appear later in the week).

No. 22 Penn State at Auburn, 2:30 p.m., Ch. 4

Nittany Lions held off Tigers 28-20 in Happy Valley last year, and Auburn wasn't impressive in edging San Jose State 24-16 last week. Penn State 27, Auburn 17.

No. 11 Michigan State at Washington, 6:30 p.m., Ch. 5

Spartans get their first stiff test of the season against a Huskies team led by former Indiana QB Michael Penix Jr., who's seventh in the nation with 341 passing yards per game. Washington 34, Michigan State 30.

No. 6 Oklahoma at Nebraska, 11 a.m., Ch. 9

Nebraska wide receivers coach Mickey Joseph takes over as interim coach for the fired Scott Frost and debuts with a tough matchup. He'll have the Huskers fired up for their old Big 12 rival, but the rebuild will take time. Oklahoma 31, Nebraska 23.

Rockets are no slouches under coach Jason Candle, going to five bowls in seven seasons, but the Buckeyes have too much talent. Ohio State 45, Toledo 24.

Purdue at Syracuse, 11 a.m., ESPN2

The Orange outscored Louisville and Connecticut by a combined 79-21. Boilers will miss LB/S Jalen Graham (leg injury). Syracuse 34, Purdue 31.

SMU at Maryland, 6:30 p.m., FS1

SMU wants to relive its Pony Express glory days, but it doesn't have the horses. Maryland 35, SMU 20.

Wolverines can name their score. Michigan 48, Connecticut 10.

Southern Illinois at Northwestern, 11 a.m., BTN

Wildcats bounce back from loss to Duke. Northwestern 31, Southern Illinois 13.

Western Kentucky at Indiana, 11 a.m., BTN

Hoosiers edged Hilltoppers 33-31 last year in Bowling Green, Ky. Expect another tight game. Indiana 38, Western Kentucky 30.

Scarlet Knights will get halfway to bowl eligibility. Rutgers 49, Temple 21.

New Mexico State at Wisconsin, 2:30 p.m., BTN

Badgers will fine-tune their sluggish offense against Jerry Kill's Aggies. Wisconsin 34, New Mexico State 0.

Nevada at Iowa, 6:30 p.m., BTN