An improved 49ers team will prevent Kirk Cousins' debut from being completely smooth sailing, but the Vikings defense will put enough pressure on Jimmy Garoppolo to secure a Week 1 victory.
THREE BIG STORY LINES
Cousins debuts vs. his old mentor
49ers coach Kyle Shanahan was the offensive coordinator during Kirk Cousins' first two seasons in Washington. Cousins led the Redskins to a win in a matchup against Shanahan last year, throwing for 330 yards and two TDs.
Hughes to start in his debut?
With Mackensie Alexander doubtful because of an ankle injury, first-round pick Mike Hughes could be one of the rare rookies to start in Mike Zimmer's defense, if the Vikings open the game in their nickel package. It would be a big step for Hughes, whose footwork and defensive acumen impressed coaches.
Cook makes his return
RB Dalvin Cook figures to start, just over 11 months after tearing his ACL. If the Vikings choose to bring Cook along slowly in his first game back, they can lean on Latavius Murray, especially in short-yardage situations.
TWO KEY MATCHUPS
Vikings offensive line vs. 49ers DT DeForest Buckner