The Vikings will be without four of their starters in Detroit on Sunday.
Rookie linebacker Anthony Barr, defensive tackle Sharrif Floyd, safety Robert Blanton and left guard Charlie Johnson were all ruled out on Friday because of injuries.
It will be the second consecutive game Barr has missed because of a knee injury he initially suffered against the Bears in Week 11.
Floyd, who also has a knee injury, will be replaced by rookie defensive tackle Shamar Stephen, who has started the past three games. Barr's replacement is linebacker Gerald Hodges, who returned an interception for a touchdown on the first play from scrimmage last week against the Jets.
Johnson (ankle) and Blanton (ankle/knee) didn't practice all week after suffering injuries in the overtime victory over the Jets. Vladimir Ducasse takes over at left guard and Andrew Sendejo at strong safety.
Sendejo has been the backup at both free and strong safety. He played both positions last week with Blanton and safety Harrison Smith suffering injuries at different points in the game.
"When a starter goes down, you want to be able to step up and fill that void," Sendejo said. "That's what I did, and that's what I'm going to go in there and do. I've done that before in the past, and for the most part I've done a decent job of showing them if they need me to come in when someone goes down, they can count on me. "
Officially out
The Vikings were officially eliminated from the playoffs on Thursday when the Cardinals defeated the Rams. In an unlikely scenario — with one website giving the Vikings a .005 percent chance — the Vikings would have needed to win their remaining games and have a number of other things happen, including St. Louis winning all of its games, to make the playoffs.