Righthander Tyler Duffey sabotaged his night by botching a throw that could have started a double play, then laying pitches over the plate to Lonnie Chisenhall and Mike Napoli.
Napoli's homer was the difference in the Twins' 5-4 loss to Cleveland on Friday at Target Field.
Duffey (8-11) gave up five runs (two earned) on seven hits, with a one walk with six strikeouts.
"He tried to use all his pitches," Twins manager Paul Molitor said. "His changeup was little inconsistent. He used the fastball quite a bit. The curveball at times was good for him."
Joe Mauer homered in the first inning and Byron Buxton scored from first on Brian Dozier's double in the second. But Duffey gave it all back, and then some, in the third.
Duffey nicked Jason Kipnis with a pitch, then Francisco Lindor reached when Duffey fielded his comebacker but threw wildly to second while trying to start a double play.
"If I turn that double play, it's a different ballgame," said Duffey, who made his first start since being recalled from the minors.
Two batters later, Jose Ramirez's infield hit off Duffey's foot loaded the bases.