For the Twins veterans who've been there through so many crushing losses to the Yankees, Tuesday night was sweet.
With the Yankees and Orioles battling for first place in the American League East, the Twins came from behind with four runs in the seventh inning, getting big hits by Denard Span and Joe Mauer.
Twins closer Glen Perkins gave up a ninth-inning home run to Andruw Jones but fanned Jayson Nix to preserve the 5-4 victory before an announced crowd of 33,346 at Target Field.
The Yankees lead the Orioles by 1 1/2 games and missed a chance to expand that lead after Baltimore lost to Toronto 4-0.
"It's always good to beat the Yankees, no matter what time of year it is, even if it's spring training," Span said. "I used to love beating them, even in A-ball."
The Twins are 7-26 in their past 33 games against the Yankees, including postseason sweeps in 2009 and 2010.
New York held a 3-1 lead in the seventh inning this time, when the Twins loaded the bases with one out against Yankees starter Phil Hughes.
Pedro Florimon struck out for a big second out, and Yankees manager Joe Girardi brought in lefthander Boone Logan to face Span.