Spread out over the first nine months of the year, primaries will set the stage for the 2018 midterm elections in November. These contests will be the first test of each party's ability to field strong candidates in key pickup opportunities and fend off intraparty challenges.
The first elections will be in March. What to watch for as the primaries begin:
Some candidates have opted to take on sitting lawmakers from their own parties.
On the Republican side, President Donald Trump's former adviser Steve Bannon has threatened to support primary challengers against Republican incumbents. The March filing deadlines will be key, as challengers could emerge in Nebraska, Mississippi and Utah. Wyoming's June deadline is another to keep on the radar.
With North Carolina's primary scheduled for May 8, Rep. Robert Pittenger could be the first lawmaker to lose a contest. His primary challenger, former pastor Mark Harris, has reportedly caught Bannon's attention. Harris lost a 2016 challenge to Pittenger by just 133 votes, and he outraised Pittenger in the most recent fundraising quarter.
In Colorado's Fifth District, Rep. Doug Lamborn faces a handful of Republican challengers, including state Sen. Owen Hill and 2016 Senate candidate Darryl Glenn. Even before the June 26 primary, Lamborn could run into trouble. To get on the ballot, candidates have to either gather signatures by March 20 or receive at least 30 percent of the vote at a party assembly in April.
June and August will host a number of primaries should Senate challengers emerge. If state Sen. Chris McDaniel decides to challenge GOP Sen. Roger Wicker in Mississippi, they would face off on June 5 in the first test for a Bannon-backed Senate challenger.
Two key Senate primaries are Nevada's on June 12, with GOP Sen. Dean Heller facing perennial candidate Danny Tarkanian, and Arizona's on Aug. 28, with Republicans competing for the GOP mantle in the open-seat race.