The Twins waited 591 days for Kenta Maeda's return from elbow surgery.
The righthander struck out nine batters — four consecutively, including the side in the fifth inning — with no walks before he left Tuesday's 1-0 loss to the Marlins abruptly in the sixth inning shaking out his right pitching arm.
Afterward, Twins manager Rocco Baldelli called Maeda "fine" and praised his command and crispness with his off-speed pitches.
"That's the Kenta we saw a bunch of in 2020, the guy that was second in the Cy Young [voting]," Baldelli told reporters in Miami. "Really an exceptional start. He's only, in my opinion, going to get better from here."
Cy Young winner Sandy Alcantara threw a three-hitter for the Marlins in the first complete game in the majors this season. The one-run loss was the Twins' first after a 4-0 season start that only Tampa Bay matched in all of baseball.
It also was the first time they trailed in their first five games, from one out in the second inning on, until the Marlins turned a double play to end the game.
Maeda allowed only Marlins right fielder Avisail Garcia's 388-foot home run into the left-field bleachers in that second inning.
But that's all the Marlins needed because Alcantara stopped the Twins cold after they had scored 18 runs in their previous two games against Kansas City and Miami.