In "Big Eyes," Amy Adams paints a picture of the male-centric 1960s.

According to Amy Adams, octogenarian artist Margaret Keane had never heard of the actress when approached last year and asked, "Are you OK with Amy Adams playing you?"

"She was like, 'Who's Amy Adams?' " the five-time Oscar nominee recounts with a chuckle. "But she went and did her research and watched some films, and so I ultimately got the seal of approval, which is good."

Very good. Adams made the list of best-actress nominees for a Golden Globe (in a musical or comedy), and she may very well be hearing her name again come Academy Award time.

In "Big Eyes," Tim Burton's seriously funny, seriously moving account of Keane's life, Adams inhabits a woman who was both the victim of her times — a "Mad Men"-esque 1960s — and the victim of a husband who claimed credit for the portraits of orb-eyed waifs and tearful clowns that she created.

Signed simply "Keane," these kitschy paintings caught on like forest fires. Thanks to Walter Keane's entrepreneurial flair, the bright-hued images of crying cats, pitiful puppies and "hobo kids" with the world's sorrows in their eyes sold as fast as Margaret could paint them. Posters and prints, books and cards followed, and Walter raked in the bucks.

"Margaret never saw a dime from Walter," said Adams, who spent a day in Keane's Napa County studio to prepare for the role. "She was like, 'I knew I wouldn't see that money. It never was about the money, it was about telling the truth and getting my name back.' "

Christoph Waltz, the Austrian who has won two supporting-actor Academy Awards (for his work in Quentin Tarantino's "Inglourious Basterds" and "Django Unchained"), plays Walter with a buoyant bonhomie and a huckster's gleam.

In the early going of "Big Eyes," Margaret leaves a first, smothering marriage and has relocated with her young daughter. She meets Walter, who introduces himself as a fellow artist, and they start to date. Soon, he's on his knees, proposing.

Not long thereafter, she discovers that he is claiming as his the paintings he has been putting up in coffeehouses and nightspots around town. She goes along with the deception, meekly, because he insists they are more salable if deemed the work of a man — especially a man who has lived as colorful and storied a life as he.

Colorful stories are all they prove to be.

Adams, 40, has explored this era before, and the way women were viewed in a society dominated by men. In "Doubt," she was a naive young nun teaching school in 1960s New York. In "Catch Me If You Can," she's the gullible nurse who falls in love with the con artist, played by Leonardo DiCaprio.

"These are both women that came out of the same general time frame. And I had done research on women's roles at that time, and I read 'The Feminine Mystique' and researched the early feminist movement," she said.