The Twins entered Thursday night knowing they had 65 regular-season games remaining, with 13 of them -- or 20 percent -- coming against the Tigers.
The teams had played five games this year, and Detroit had won them all, without using Justin Verlander once.
Verlander has been remarkable this season, refining his arsenal to become one of the most dominant pitchers in baseball.
He put it all on display at Target Field in the opener of a four-game series, as the Tigers defeated the Twins 6-2.
Verlander (13-5) allowed one run on five hits over eight innings, with no walks and nine strikeouts, lowering his ERA to 2.24 and raising his American League-leading strikeout total to 162.
"He made it look really easy tonight," said Carl Pavano (6-7), who kept the Tigers scoreless for the first three innings but left trailing 5-1 after the sixth.
The sequence that should scare the Twins the most came in the second inning, after Michael Cuddyer hit a leadoff triple.
Suddenly for Verlander, it was no more Mr. Nice Guy.