FOCUS ON FIVE STORY LINES
1 Peyton passes the Ol' Gunslinger? San Francisco at Denver
Broncos QB Peyton Manning (right) needs two TD passes to tie Brett Favre's NFL record of 508. The Niners defense might be without LB Patrick Willis in this prime-time showdown.
2 Colts on a big roll Cincinnati at Indianapolis
The Colts have won four in a row after losing their first two, while Cincinnati is coming off a tie against Carolina when Mike Nugent missed a chip-shot FG to win the game. Bengals WR A.J. Green might return from an injury.
3 Big test for Chiefs Kansas City at San Diego
The Chiefs need a victory to keep pace in the AFC West. The Chargers have won five straight, but their past three victories came against teams with combined 1-17 record.
4 Marshall meets old mates Miami at Chicago
Chicago WR Brandon Marshall plays his former team, which lost in the final seconds to the Packers last week. Marshall had 167 receptions for 2,228 yards with Miami from 2010-11.
