1. CAN THE M&M BOYS STAY HEALTHY?

The goal all spring was getting Justin Morneau ready for Opening Day after he missed the final 78 games last year because of a concussion. But the bigger goal is keeping him on the field for a full season, something he hasn't done since 2008. The same goes for Joe Mauer, who spent much of spring training rebuilding leg strength after having knee surgery in December.

2. WILL THE NEW MIDDLE INFIELDERS HIT?

Second baseman Tsuyoshi Nishioka and shortstop Alexi Casilla (right) looked good defensively this spring, but it's unclear how much, if any, the Twins will lose offensively now that Orlando Hudson and J.J. Hardy are gone. Nishioka was a batting champ last year for the Chiba Lotte Marines, but other Japanese stars have struggled to hit in the majors. And the last time the Twins trusted Casilla with a starting job out of spring training, in 2009, he batted .174 in April.

3. WILL THE REVAMPED BULLPEN SPRING A LEAK?

The Twins had the majors' eighth-best bullpen ERA last year, at 3.49, but they lost four of their top relievers: Jesse Crain, Matt Guerrier, Jon Rauch and Brian Fuentes. Matt Capps and Jose Mijares are back, and Joe Nathan returns after missing last season because of an elbow injury, but it's unclear how the Twins will tackle the sixth and seventh inning when their starters tire and they are clinging to a close lead.

4. CAN FRANCISCO LIRIANO BECOME A TRUE ACE?

The Twins like their rotation depth, with five established starting pitchers and Kevin Slowey, a 13-game winner last year, available in the bullpen. They also have top prospect Kyle Gibson knocking on the door at Class AAA Rochester. But will it be enough to win the division? And, if the Twins return to the postseason, will Francisco Liriano give them an intimidating top-of-the-rotation presence?

5. WILL CONTRACTS BECOME A DISTRACTION?

Michael Cuddyer, Jason Kubel, Joe Nathan, Matt Capps and Jim Thome are eligible for free agency at season's end, and the Twins seem content to go year-to-year with Liriano and Delmon Young, who can become free agents after 2012. Will these players struggle without long-term security, or will these contract issues help push them to bigger and better things?