Doug Mientkiewicz will manage the Toledo Mud Hens, the Class AAA affiliate of the Detroit Tigers.
The hiring was reported by the Detroit Free Press on Tuesday.
Mientkiewicz is a Toledo native.
Ron Gardenhire, who managed Mientkiewicz with the Twins for three seasons (2002-04), was named the Tigers manager last month.
Mientkiewicz, 43, has five seasons of minor league managerial experience with Class A Fort Myers in 2013-14 and 2017 and Double-A Chattanooga in 2015-16.
He was fired by the Twins following Fort Myers' season.
Mientkiewicz played for 12 seasons in the major leagues, including 1998-2004 with the Twins. He won a Gold Glove at first base in 2001 and was a lifetime .271 hitter.
When Gardenhire was fired as Twins manager in 2014, Mientkiewicz was one of the finalists to replace him. That job went to Paul Molitor.