A new dominant variant pushed the viral load in Twin Cities wastewater up 13% in the week ending June 20, disrupting a steady decline in COVID-19 levels since mid-May.
Health officials cautioned against hasty interpretations of the reversal, one week after sewage sampling at the Metropolitan Wastewater Treatment Plant in St. Paul found a 12% decline in the presence of the coronavirus that causes COVID-19.
While wastewater levels have accurately forecast shifts in COVID-19 activity before infection numbers changed, they can be distorted by high or low readings on an individual day. The viral load found at the metro plant on June 19 was substantially higher than the rest over the past week.
"It's impossible to say whether this uptick represents the beginning of an increasing trend in the viral load at the Metro Plant, or if it's just a bump along the way," said Steve Balogh, a principal research scientist at the plant.
Another week of wastewater data could be more telling about whether COVID-19 levels are rising in Minnesota again or perhaps leveling off at a steady, endemic level into the future.
One thing that is clear: The fast-spreading BA.4 and BA.5 coronavirus subvariants made up 55% of the viral load identified in Twin Cities wastewater over the past week.
Health officials believe BA.5 will become the dominant source of COVID-19 in Minnesota this summer. Genomic sequencing of a sampling of positive specimens has found that 93 involved BA.5 and that the subvariant exists across the state, according to the Minnesota Department of Health.
Balogh said the variant has at least the potential to "drive the total viral RNA level higher" in wastewater samples in the coming weeks.