Shares were mostly higher in Asia on Thursday, helped by progress toward rolling out coronavirus vaccines and talk of reaching a compromise on new help for the U.S. economy.
Shares rose in Hong Kong, Tokyo, Seoul and Sydney but fell in Shanghai.
The rollout of a vaccine in the U.S. could begin this month, if regulators give their approval. Drugmakers Pfizer and BioNTech said they won permission for emergency use of their COVID-19 vaccine in Britain, which will be one of the first countries to begin vaccinating its population against the virus.
The vaccine is the world's first coronavirus shot that's backed by rigorous science and a major step toward eventually ending the pandemic and helping economies return to normal.
"The vaccine has been the big prize for risk markets," Stephen Innes of Axi said in a commentary. Vaccinations will reduce virus counts, resulting in a "collective demand lift for the world economy, and global geopolitical risk has also diminished after the U.S. presidential election. A much clearer view across the valley to economic recovery should mean more upside," he said.
Hong Kong's Hang Seng edged 0.2% higher to 26,582.85 and the Nikkei 225 in Tokyo was almost unchanged at 26,806.37. South Korea's Kospi added 0.2% to 2,680.58 and the S&P/ASX 200 in Australia picked up 0.4%, to 6,613.60.
The Shanghai Composite index shed 0.5% to 3,432.47.
Overnight, the S&P 500 index rose 0.2% to an all-time high of 3,669.01, a second straight record close. It spend much of the day drifting between small gains and losses. A pullback in technology stocks and companies that rely on consumer spending kept the gains in check.