Adam Thielen will not play in Monday night’s game in Seattle, after a setback during the Vikings’ first practice after the bye week caused the Vikings to rule him out because of an ongoing right hamstring injury.

Defensive tackle Jalyn Holmes was also downgraded to out with a non-injury-related issue.

Thielen has played just seven snaps since he first injured his hamstring on Oct. 20. He had targeted Monday’s game in Seattle as an opportunity to return, but sources said Thielen’s injury flared up on Tuesday, when the Vikings went through a brief outdoor practice after returning from their bye week.

Thielen did not practice on Wednesday and was listed as a limited participant Friday and Saturday.

He said Friday his hamstring was “getting there” and that everything was going “according to plan” but that he wouldn’t play unless his hamstring was 100 percent healed.

In Saturday’s injury report, the only starter listed as out was linebacker Ben Gedeon (concussion). Listed as questionable were Thielen, nose tackle Linval Joseph (knee), safety Harrison Smith (hamstring), safety Anthony Harris (groin) and defensive tackle Shamar Stephen (knee).