The Vikings have beaten the Saints twice in 13 months at U.S. Bank Stadium, but with injuries at a number of key positions on defense, they could have a tough time slowing down Drew Brees and company in time to get a third victory against New Orleans, especially if it's a big day for Alvin Kamara.
Three Big Story Lines
Moving on from the miracle
The Vikings and Saints have both taken great pains this week not to frame Sunday's game as any kind of grudge match after Minnesota's 29-24 victory in the playoffs. That hasn't stopped the questions about Stefon Diggs' game-winning TD in January, but both teams have plenty to play for this year.
Brees at his best
The quarterback, who turned 39 the day after the Vikings' playoff victory over the Saints, could be on his way to his first league MVP award in his 18th season. He has completed a league-high 77.3 percent of his passes this season, throwing 13 for touchdowns without an interception.
Griffen ready to return
Defensive end Everson Griffen came back to the Vikings this week following his five-week absence while receiving treatment for mental health issues, and he's expected to play Sunday night. It remains to be seen what kind of a role the three-time Pro Bowl selection will have.
Two Key Matchups
Vikings secondary vs. Saints WR Michael Thomas