Will Steelers snap Pats' stranglehold?
Home-field advantage throughout the AFC playoffs likely will be decided in Pittsburgh. If the Patriots win, they'll be tied with Pittsburgh at 11-3 and hold the tiebreaker. If the Steelers win, they'll be two games up with two to go and hold the tiebreaker. New England is 10-3 against Pittsburgh during the Bill Belichick era, including last year's 36-17 win in the AFC title game. Pittsburgh is 7-1 in games decided by fewer than seven points.
Can Seattle catch Rams in the West?
Right now, Seattle (8-5) is outside the playoff field. But a win against the visiting Rams (9-4) would sweep the season series and give the Seahawks the head-to-head tiebreaker in the NFC West. Russell Wilson needs 18 yards rushing and two TD passes to become the first player in NFL history to have multiple seasons with at least 30 TD passes and 500 yards rushing. Seattle won at Los Angeles 16-10 in Week 3.
How will the Eagles respond?
In the first game since Carson Wentz's season-ending injury, the Eagles (11-2) can clinch the No. 1 seed in the NFC with a win over the Giants (2-11) and a Vikings loss. Philly has beaten the Giants in six of the past seven meetings and is a nine-point favorite on the road. But this isn't a layup for the team that must adjust quickly to the second Nick Foles, above, era in Philadelphia.
Can Buffalo stay in the playoff picture?
The Bills haven't made the playoffs since Antoine Winfield's rookie season (1999). They started 5-2 but are wobbling through a 2-4 slide heading into a home game against the Dolphins. Miami is 6-7 but ended New England's eight-game winning streak last week. Buffalo ranks 31st in passing and 16th in scoring defense but holds the AFC's sixth playoff seed. The Dolphins are 10th in the AFC but could re-enter the wild-card picture with a win.
Will Titans bounce back or fade away?
This is a big week for Marcus Mariota and the 8-5 Titans. A week after getting beat by four Arizona field goals, they travel to San Francisco to play a 49ers team that's 3-10 but has won three of four and two straight on the road in Jimmy Garoppolo's first two starts. If Tennessee can stay within a game of Jacksonville (9-4), it can win the AFC South if it beats the visiting Jaguars in Week 17.