1. Can Buffalo join the new millennium?

The last time Buffalo participated in the playoffs was Jan. 8, 2000. But the Bills are 2-1, leading the league in points allowed (12.3) and have not allowed a touchdown pass. Coming off a surprise home win over the Broncos, Buffalo faces a stiffer challenge when it travels to 3-0 Atlanta. Matt Ryan threw three picks, including a pick-six, to keep Detroit in the game last week. The Falcons will be more comfortable back home.

2. Can ‘Mr. London’ avoid a letdown?

In his past three games in London, Blake Bortles is 3-0 with eight touchdowns and no interceptions. But can the UK’s favorite QB transfer that to the States against a Jets team coming off its own surprise victory? A week ago, the Ravens expected to become the first team since the 1961 Chargers to notch at least four interceptions in each of its first three games. Bortles threw four TDs and no picks in a rout.

3. What’s wrong, Cam, Pats ‘D’?

The Patriots can’t seem to stop anybody, while Panthers quarterback Cam Newton, pictured, can’t seem to get going. They meet in Foxborough with New England expected to ride Tom Brady to a third straight win. Newton threw three picks last week as the Panthers were held to 13 points by the Saints’ weak defense. He has four interceptions and two touchdowns and is averaging fewer than 200 yards passing. The Patriots are last in points allowed (31.7).

4. Jake Elliott meets Younghoe Koo

Eagles kicker Jake Elliott was carried off the field after a walkoff 61-yarder to beat the Giants last week. Chargers kicker Younghoe Koo has missed two last-second attempts in three games. They meet in Los Angeles at tiny Stubhub Center. The 27,000-seat stadium was pro-opponent again last week when the Chiefs dominated the Chargers in a 14-point victory. Chargers QB Philip Rivers threw three INTs, no touchdowns and posted a 37.2 passer rating.

5. Has Kansas City met its match?

The Chiefs are considered the NFL’s best team. But titles like that tend not to last long. A week ago, Washington hosted the Raiders and their No. 1-ranked offense. The Redskins surprised everybody by dominating Oakland on the scoreboard and in total yards (472-128). Kirk Cousins, not Derek Carr, looked extraordinary with 365 yards passing and only five incompletions. Kansas City is better defensively and is at home in prime time. But look out for Washington.