Two people are dead and two are in custody after a domestic-related shooting Friday night at a south Minneapolis home, police said.

The shooting took place just after 5 p.m. in the 2200 block of 10th Avenue S. The victims are believed to have lived at the home, said John Elder, a Minneapolis police spokesman.

Information regarding the victims’ ages and gender were not immediately available. The Hennepin County medical examiner will release the victims’ identities and official cause of death.

Elder called the shooting a “targeted, isolated incident” and said there is no indication of any threat to public safety. One of the two people in custody is considered a suspect, Elder said. The other is being held for protection.

Neighbors who knew the family involved said they witnessed the father, whom they identified only by his first name, surrender to police Friday evening after they heard multiple gunshots. Several fellow Ventura Village residents described him as a friendly handyman who fixed up the home his family rented near the intersection of 10th Avenue S. and E. 22nd Street.

Any updates on the case will be put on the police department’s new website: www.InsideMPD.com.