The Twins have the earliest opener in team history in 2020, when they start the season March 26 at Oakland.
The first game at Target Field will be Thursday, April 2, also against the Athletics.
The Twins' schedule includes interleague games against the National League West. They'll play the Los Angeles Dodgers both at Target Field and at Dodger Stadium, will have home series against San Francisco and Colorado, and will play at Arizona and San Diego.
The Twins also will play two interleague series against the Brewers.
Home games against Boston (April 24-26), the Yankees (June 18-21) and the Astros (July 31-Aug. 2) are highlights. Target Field games on weekdays will again start at 6:40 p.m. in April, May and September.
The Twins will face each team in the AL Central 19 times.
Cruz cleared
Twins designated hitter Nelson Cruz, on the 10-day injured list because of a ruptured tendon in his left wrist, was cleared to resume baseball activities Monday.
Cruz was in New York to be examined by hand specialist Dr. Thomas Graham.