Donald Trump's vice presidential pick hasn't seen eye-to-eye with him on key issues animating the Republican's campaign, including free trade and banning Muslims.
Pence, the governor of Indiana, has called for "swift adoption" of the Trans-Pacific Partnership trade pact with Asian countries. "Trade means jobs, but trade also means security," he said in September 2014.
Trump, by contrast, has made opposition to free-trade deals a centerpiece of his campaign, blasting the TPP as "disastrous," "terrible" and "a continuing rape of our country" by special interests.
In December 2015, Pence joined a group of Republican officials in rebuking Trump's controversial proposal to prohibit Muslims from entering the United States, which won the support of a large majority of GOP voters and boosted Trump in the primaries.
"Calls to ban Muslims from entering the U.S. are offensive and unconstitutional," Pence wrote on Twitter at the time. "Our Constitution guarantees the free exercise of religion. The U.S. cannot discriminate on the basis of religion."
Trump and Pence also have subtle but pronounced differences on social issues. Unlike Trump, Pence wants to make abortion illegal even in cases of rape and incest, and co-sponsored a controversial proposal in 2011 to redefine rape cases connected to abortion laws as "forcible rape."
Unlike Trump, Pence has also pushed for a constitutional amendment banning same-sex marriage, an issue the presumptive nominee barely mentions.
Still, Pence's credibility with evangelical Christians — a group that has mixed feelings for Trump — along with his tax-cutting record as governor and anti-spending record as a congressman are key assets he brings to the ticket. Trump's image is shaky with conservatives, with whom Pence has closely associated throughout his 15-year career.