No. 3 Ohio State and No. 13 Wisconsin, the teams favored to play for the Big Ten championship, have already had a combined three games canceled because of COVID-19.
A spate of postponements in the Southeastern Conference has created the distinct possibility that neither No. 1 Alabama nor No. 6 Florida will play all its games.
And the most important Atlantic Coast Conference game of the season was played without the Heisman Trophy favorite, Clemson quarterback Trevor Lawrence, because he was recovering from the coronavirus.
As virus disruptions mount and the end of college football's regular season draws closer, the possibility grows that conference championships, major awards and even College Football Playoff participants will be determined in large part by COVID-19.
"We've all accepted this is anything but a normal year," ACC Commissioner John Swofford said.
Three more games were called off Thursday, including Pittsburgh at Georgia Tech in the ACC, raising the number of games involving Bowl Subdivision teams to be postponed or canceled since revised schedules were set in late August to 58 — including 21 in the past two weeks.
The total number of FBS games played so far is 310, meaning about 15% of the schedule through 10 weeks has been impacted. The number has increased recently in part because all FBS conferences are now playing, with the Pac-12 and Mid-American Conference returning last week, but it has also coincided with surging COVID-19 cases across the country.
In major college football, five postponed games have already been made up and another 25 have been rescheduled with the Dec. 19 end date a little more than a month away. As days come off the calendar and make-up dates become tougher to find, conferences will have to put more emphasis on the games that matter most.