Turkish tanks and artillery attacked the Islamic State in Iraq and the Levant in retaliation for the suicide bombing in Istanbul that killed 10 tourists, Turkey’s prime minister said Thursday — the country’s first significant strike against ISIL in months.

Prime Minister Ahmet Davutoglu said some 200 extremists had been killed over the past 48 hours in Turkey’s offensive against ISIL along the Syria-Turkish border and near a Turkish camp in Iraq.

He said Ankara acted after determining that ISIL was responsible for the “heinous” suicide bombing Tuesday in Istanbul’s main tourist district. All of the dead were German tourists.

“Turkey will continue to punish with even greater force any threat that is directed against Turkey or its guests,” Davutoglu said.

Associated Press