– Kevin Anderson stunned third-seeded Andy Murray at the U.S. Open to reach his first Grand Slam quarterfinal.

Murray had made the quarterfinals in his last 18 Grand Slam tournaments before losing to the 15th-seeded South African 7-6 (5), 6-3, 6-7 (2), 7-6 (0) on Monday. The two-time major champion was trying to rally from two sets down for the second time in three rounds.

"Disappointing to lose because of that," Murray said about his earlier-than-usual exit. "Obviously that's many years' work that's gone into building that sort of consistency."

For the 6-foot-8 Anderson, it marked a real breakthrough: He entered with an 0-7 record in fourth-round matches at majors, including when he had a two-set lead against Novak Djokovic before losing at Wimbledon two months ago.

"I'm a little lost for words right now," the 29-year-old Anderson said.

Another quarterfinal matchup was to be determined later Monday, when No. 2 Roger Federer faced No. 13 John Isner, the last American man in the tournament, while No. 6 Tomas Berdych of the Czech Republic met No. 12 Richard Gasquet of France.

Two women's quarterfinals will be No. 2 Simona Halep against No. 20 Victoria Azarenka, and No. 5 Petra Kvitova against No. 26 Flavia Pennetta.

Associated Press