Tevin Coleman scored three of his four touchdowns in the first half, rookie Nick Bosa had three sacks and an acrobatic interception and the San Francisco 49ers rolled to a 51-13 victory over the Carolina Panthers on Sunday in Santa Clara, Calif., in their highest-scoring game in 26 years.

The 49ers (7-0) delivered perhaps their most complete performance of the season against the Panthers (4-3), who had won four straight games.

"We know what we have in this building," said 49ers cornerback Richard Sherman, who had an interception. "The same thing we've said since training camp, we'll continue to say. We knew the talent we have, we just have to execute."

Jimmy Garoppolo and the offense carved up Carolina's defense with 232 yards rushing and a pair of scoring passes in San Francisco's most prolific offensive game since beating Detroit 55-17 on Dec. 19, 1993.

San Francisco intercepted three passes from Kyle Allen, who came into the game with no interceptions on 153 career attempts while winning his first five starts in place of injured starter Cam Newton. They also had seven sacks, and Bosa made a leaping interception and 46-yard return on the final play of the third quarter.

Seattle 27, Atlanta 20: Russell Wilson threw two touchdown passes to DK Metcalf, Chris Carson ran for 90 yards and a score, and the visiting Seahawks (6-2) beat the Falcons (1-7). Seattle led 24-0 at halftime as the Falcons offense floundered in its first start without quarterback Matt Ryan in 10 years.

AFC

No. 300 for Belichick

New England 27, Cleveland 13: The visiting Browns (2-5) turned the ball over on back-to-back-to-back plays in the first quarter, leading to a pair of Patriots touchdowns that changed a three-point lead into a runaway for the Patriots (8-0), who gave coach Bill Belichick his 300th victory. Nick Chubb ran for 131 yards, but he fumbled on consecutive plays before Baker Mayfield was intercepted on a shovel pass.

Indianapolis 15, Denver 13: Adam Vinatieri overcame two early misses and made a 51-yard field goal with 22 seconds left, helping the host Colts (5-2) overtake the Broncos (2-6), who blew a 13-3 lead.

Jacksonville 29, N.Y. Jets 15: New York QB Sam Darnold was sacked eight times and threw three interceptions in a loss to the host Jaguars (4-4). Darnold was picked off twice in the fourth quarter, including one that set up Gardner Minshew's game-sealing score to D.J. Chark. The Jets are 1-6.

Houston 27, Oakland 24: Deshaun Watson's third TD pass, a 9-yarder to Darren Fells with about six minutes left, gave the host Texans (5-3) their first lead against the Raiders (3-4).

iNTERCONFERENCE

Eagles run over Bills

Philadelphia 31, Buffalo 13: Miles Sanders scored on a 65-yard run, and the Eagles (4-4) rushed for 218 yards and broke the game open against the host Bills (5-2) with two TDs in an 83-second span.

Tennessee 27, Tampa Bay 23: Ryan Tannehill threw an 8-yard touchdown pass to A.J. Brown with 6:55 left, and the host Titans (4-4) beat the Buccaneers. Tampa Bay (2-5) had four turnovers, all by QB Jameis Winston.

L.A. Rams 25, Cincinnati 10: Cooper Kupp caught seven passes for a career-best 220 yards, Jared Goff threw for two scores and the host Rams (5-3) handled the 0-8 Bengals. Goff threw for 273 of his 372 yards in the first half.