Red Sox handle Oakland's switch-pitcher Pat Venditte

BOSTON – Oakland's Pat Venditte became the first pitcher in 20 years to throw with both arms in the same game, but the Boston Red Sox beat the Athletics 4-2 on Friday night.

Dustin Pedroia had three hits for Boston, which led 3-0 after four innings and ended Oakland's four-game winning streak.

Wade Miley (5-5) allowed an RBI single to Mark Canha in the fifth, but Boston made it 4-1 on a run-scoring single by Brock Holt in the bottom of the inning off Scott Kazmir (2-4).

Lawrie led off the seventh with his fifth homer of the year.

Miley allowed two runs on six hits in 7 ⅓ innings. Junichi Tazawa got the last two outs in the eighth and Koji Uehara escaped a second-and-third jam in the ninth for his 12th save in 14 opportunities.

Venditte entered the game to start the eighth for his major league debut after being called up Friday from Triple-A Nashville. The Fenway organist played Joni Mitchell's, "Both Sides, Now," as Venditte made his way to the mound.

He started throwing warm-up pitches with his right hand then switched to his left to face lefty Holt, who grounded out to first.

Venditte uses a single, six-finger glove on whichever hand he is not using to throw.

Boston took a 1-0 lead in the first when Pedroia singled and scored when Holt doubled and left fielder Ben Zobrist made an error trying to field the ball. Ramirez hit a sacrifice fly in the third. In the fourth, Xander Bogaerts doubled and scored on Mookie Betts' infield single and a throwing error by third baseman Lawrie.