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Patrick Mahomes is having his worst season statistically and the Chiefs keep losing playmakers to injuries.
The two-time defending Super Bowl champions are 6-0 anyway.
Kansas City is the NFL's only unbeaten team following an ugly 28-18 victory over San Francisco in a Super Bowl rematch on Sunday that looked more like a preseason game.
Mahomes, a two-time NFL MVP and three-time Super Bowl MVP, threw two picks and posted a career-worst 44.4 passer rating against the 49ers, but he made enough plays, including a nifty 33-yard run, to lead the Chiefs to their 12th straight win, dating to last year.
Mahomes has more interceptions (eight) than touchdowns (six) this season and a career-low 82.5 passer rating. But a stingy defense and a strong run game has led the way for Kansas City, which lost cornerback Jaylen Watson and receiver JuJu Smith-Schuster to injuries in the latest win.
The Chiefs already are without No. 1 receiver Rashee Rice and top running back Isiah Pacheco, plus Marquise ''Hollywood'' Brown has yet to play.