Playing its second game without leading scorer Seimone Augustus, the Minnesota Lynx fell 83-70 at Chicago on Tuesday night.
The loss snaps the defending WNBA champs' win streak at 11 games.
Minnesota, which has wrapped up the No. 1 seed in the Western Conference for the playoffs, scored just seven points in the second quarter.
Chicago had lost two previous meetings this season by double-digit points. The Sky on Tuesday was led by 19 points from guard Epiphanny Prince.