Louisiana State fired coach Les Miles and offensive coordinator Cam Cameron on Sunday, and promoted defensive line coach Ed Orgeron to interim head coach.
The moves came less than 24 hours after Miles briefly watched his players celebrate what they thought was a last-second winning touchdown pass at Auburn, only to walk off the field with a loss after officials determined on video replay that time had expired before the ball was snapped.
It was the latest of several frantic finishes in which the clock management of a Miles-coached offense had come under scrutiny.
"Coach Miles has done a tremendous job here and he's been a great ambassador for our university, which makes this even more difficult," LSU athletic director Joe Alleva said in a written statement. "However, it's apparent in evaluating the program through the first month of the season that a change has to be made.
"We have an obligation to our student-athletes to put them in the best position to have success on the football field each week."
Miles' firing, reported first by the Advocate of Baton Rouge, came hours after LSU (2-2, 1-1 Southeastern Conference), which was ranked 18th last week, dropped out of the Top 25 in the latest AP poll released Sunday afternoon.
Miles, who was in his 12th season, went 114-34 at LSU, the second-most victories in school history behind Charles McClendon's 137 victories from 1962 to 1979.
Cameron, an old friend of Miles' from when they were both assistants at Michigan in the 1980s, joined LSU in 2013.