Several changes are in store for Interstate 35E drivers in St. Paul and the eastern suburbs as new lane configurations are phased in over the few days.

To the north, the southbound lanes of I-35E closed between the Forest Lake split and County Road E in Vadnais Heights, one of four major road closures that will affect metro-area traffic through the weekend.

Motorists in the west metro face another weekend of road closures as the Minnesota Department of Transportation shuts down the southbound lanes of Hwy. 100 at Crosstown Hwy. 62 Friday through Monday morning.

Carpoolers heading to Saturday’s Vikings game at TCF Bank Stadium won’t be able to use the reversible toll lanes on I-394 between Hwy. 100 and downtown Minneapolis. And drivers in Eden Prairie can expect delays on Hwy. 212.

Off the mainline, fun and frivolity take over portions of Washington and 1st Avenues N. in the North Loop as Minneapolis holds another edition of Open Streets from 11 a.m. to 5 p.m. Sunday.

Also look for extra traffic in downtown St. Paul for the Saints home games Friday through Sunday at CHS Field and the Foo Fighters show Saturday night at the Xcel Energy Center.

Here are some specifics:

I-35E: No two trips are likely to be the same, so pay close attention to signs through Little Canada, Maplewood and St. Paul. Traffic will gradually be switched over to the newly constructed southbound lanes. Expect nightly closures in both directions from 7 p.m. to 6 a.m. Northbound I-35E also will be reduced to two lanes on Sunday to move barriers and prepare for traffic shifts. Ramps will begin opening on Monday and Tuesday. The ramp from southbound I-35E to southbound Hwy. 52 will close Tuesday.

Hwy. 100: The southbound lanes over the Crosstown will close until 5 a.m. Monday. Also, the ramps to southbound Hwy. 100 and the Crosstown will be closed.

I-394: All general traffic lanes will be open, but motorists can expect lane closures and delays between Hwy. 100 and downtown Minneapolis as crews continue sanding down the pavement. The reversible lanes between Hwy. 100 and downtown Minneapolis will be closed until 5 a.m. Monday.

Hwy. 212: At Shady Oak Road, motorists will be routed up and down exit and entrance ramps as crews take down part of the Shady Oak Road overpass. The work is expected to wrap up by 5 a.m. Monday.