First, Patrick Mahomes went down. Then, it was Micah Parsons.
The NFL lost two of its all-time greatest players to serious knee injuries in a span of a few hours on Sunday, ruining a day filled with exciting comebacks and fascinating stories.
Forty-four-year-old Philip Rivers played his first game in 1,800 days and nearly led the 14-point underdog Indianapolis Colts to a stunning upset against Seattle before Jason Myers kicked a 56-yard field goal with 29 seconds left to lift the Seahawks to an 18-16 victory.
Reigning NFL MVP Josh Allen led the Buffalo Bills from a 21-0 deficit to a 35-31 victory at New England, snapping the Patriots' 10-game winning streak and preventing them from clinching the AFC East.
Rookie quarterback Tyler Shough rallied the New Orleans Saints to a 20-17 comeback victory over the Panthers capped by Charlie Smyth's 47-yarder as time expired, damaging Carolina's chances to win the NFC South and boosting Tampa Bay's hopes.
Matthew Stafford and the Los Angeles Rams overcame a 10-point deficit and rolled past the Lions 41-34, dampening Detroit's playoff bid. The Rams lost three-time All-Pro wide receiver Davante Adams to a hamstring injury in the game. He could miss Thursday night's game at Seattle, a battle for first place in the NFC West.
Jalen Hurts played like the Super Bowl MVP and the Philadelphia Eagles snapped a three-game losing streak with a 31-0 rout over the woeful Las Vegas Raiders.
But the injuries to Mahomes and Parsons overshadowed everything else that happened in Week 15.