Tiny Bodø/Glimt produced another Champions League shock by stunning last year's beaten finalist Inter Milan 3-1 in the playoffs on Wednesday.
The Norwegian underdog followed up back-to-back wins against Manchester City and Atletico Madrid by securing a two-goal advantage going into next week's second leg in Milan.
Anthony Gordon scored four goals in the first half as Newcastle routed Qarabag 6-1.
Atletico drew 3-3 away to Club Brugge and Bayer Leverkusen has a 2-0 lead after its first leg at Olympiacos.
Bodø/Glimt's latest upset
Bodø/Glimt is fast becoming the unlikely story of this season's Champions League, producing one upset after another.
After booking its place in the playoffs with wins against City and Atletico, it strengthened its chances of advancing to the round of 16 with victory against Italian league leader Inter.
Sondre Fet put the home team ahead after collecting Kasper Hogh's backheel in the 20th minute.