Alyssa Milano has made a career out of playing small-screen sweethearts, from Samantha on "Who's the Boss?" to Rebecca on the upcoming ABC sitcom "Romantically Challenged." Not that she wouldn't mind getting a little wilder to work with one of her good friends.

NEAL JUSTIN

"I feel like the comedy I did on 'Charmed' was pretty outrageous. I mean, I was a genie in a bottle and a mermaid. But I'd love to do 'The Sarah Silverman Program.' I have great respect for her and what she does. I don't think there's any other women doing comedy like she's doing."