Buffalo Bills running back LeSean McCoy is out indefinitely after revealing he had a setback with his hamstring injury last week.

McCoy spoke about the setback for the first time Friday. He said he was making progress in his recovery from the left hamstring injury before Buffalo's Week 3 game against the Dolphins, but hurt it again on Sept. 24. McCoy attempted to play through the injury in Buffalo's 41-14 win over the Dolphins but ran for just 16 yards on 11 carries.

"After [Week 2 against New England] I was getting better, feeling better," McCoy said. "And then that Thursday I kind of hurt it again and that's where it went wrong. I tried to really push it. I guess I messed something up."

McCoy originally injured his hamstring at a training camp practice on Aug. 18.

The 5-11, 208-pound running back is known for his speed and cutting ability, which is compromised by the injury.

"I'm not the bruising type to be running through everybody," McCoy said. "My thing is making them miss and getting out of there. If you can't do that, you can't do anything."

Brees expected to play

Saints coach Sean Payton said he expects quarterback Drew Brees to start Sunday night against the Cowboys.

Brees, who has a bruised throwing shoulder, missed the Saints game last Sunday.

Cowboys weakside linebacker Sean Lee said the team has expected all along that Brees would be the starter.

"Being the quarterback he is, obviously it'll be an incredible challenge," Lee said. "He's a Hall of Fame-type of guy. We've played him before. He's an unbelievable quarterback and an unbelievable challenge and we knew with a guy like that, he's fought through injuries before, so we knew he probably would be playing."

Cutler questionable

Quarterback Jay Cutler and receiver Alshon Jeffery were among seven Bears players listed as questionable for this weekend's home game against Oakland.

Cutler has been nursing a hamstring he injured trying to make a tackle two weeks ago following an interception. Jeffery has the same injury.

Coach John Fox says Cutler will play if he is cleared by team doctors. Otherwise, Jimmy Clausen will make his second straight start.

Luck a game-time call

Colts quarterback Andrew Luck likely will be a game-time decision to play against Jacksonville on Sunday.

He was listed as questionable after he was limited in practice for the third straight day because of a sore right shoulder. Coach Chuck Pagano gave no indication to the extent of Luck's participation or how much he has thrown this week.

If Luck doesn't play, Matt Hasselbeck is expected to start


•Former NFL star Irving Fryar was sentenced to five years in prison for his role in a mortgage scam. Both Fryar and his mom were convicted in August of applying for multiple mortgage loans in quick succession while using the same property as collateral.

•Dolphins left tackle Branden Albert is doubtful to play against the Jets on Sunday because of an injured left hamstring.

•The Jaguars will be without receiver Marqise Lee (hamstring) and right guard Brandon Linder (shoulder) at Indianapolis on Sunday.

•The Falcons will be without running back Tevin Coleman (ribs), tight end Jacob Tamme (concussion) and safety Ricardo Allen (knee) for Sunday's game against the Texans.

•Packers receiver Davante Adams (ankle) is questionable to play Sunday against San Francisco.