Big Ten football picks: Blue blood matchups take over Week 10

Ohio State and Indiana both have intriguing matchups, but No. 23 USC traveling to Nebraska to face the Cornhuskers could be the game of the week.

The Minnesota Star Tribune
October 30, 2025 at 10:00PM
What looked like the game of the year once the season started, Ohio State vs. Penn State has lost muster with the Nittany Lions' struggles and James Franklin's firing. (Jay LaPrete/The Associated Press)

If you’re looking for old-school, 1970s and ’80s blue blood matchups, the Big Ten has you covered this week.

Penn State at No. 1 Ohio State, and No. 23 USC at Nebraska.

That’s a combined 21 national championships in the poll era (1936-present). While the bloom is off Penn State’s rose and Nebraska was exposed at Huntington Bank Stadium, both still are dangerous enough to push a favorite.

(Note: All games Saturday. The Gophers-Michigan State prediction will run in the GameDay preview package.)

Three with intrigue

Penn State at No. 1 Ohio State | 11 a.m. | Fox

  • The Buckeyes have beaten the Nittany Lions eight consecutive times and in 12 of the past 13 meetings. With Indiana charging hard down the Big Ten homestretch with the Buckeyes in sight, don’t expect Ohio State to falter against a reeling Penn State team. Ohio State 34, Penn State 14

    No. 23 USC at Nebraska | 6:30 p.m. | NBC

    • The Trojans and Cornhuskers have met only six times in their history, with USC holding a 5-0-1 advantage, including a 28-20 win in Los Angeles last year. The Trojans, though, are averaging 52 points at home and 29.7 on the road. The Huskers, averaging 40 at home, earn a mild upset. Nebraska 28, USC 24

      No. 2 Indiana at Maryland | 2:30 p.m. | CBS

      • The Terrapins won three straight against the Hoosiers from 2021 to 2023, but that was before coach Curt Cignetti landed in Bloomington and shook up the college football world. Indiana keeps piling up wins. Indiana 38, Maryland 17

        Keep an eye on

        Purdue at No. 21 Michigan | 6 p.m. | BTN

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        • The Boilermakers have lost six consecutive against the Wolverines, reaching 20 points only once. That trend continues as Michigan tries to work its way into playoff contention. Michigan 30, Purdue 17

          Rutgers at Illinois | 11 a.m. | NBC

          • The Scarlet Knights got the big plays at the right time to edge Purdue, while the Fighting Illini wilted in the second half at Washington. This week, Illinois rebounds to win a tight one. Illinois 24, Rutgers 21

            Season record

            • Week 1: 18-0
              • Week 2: 18-0
                • Week 3: 13-2
                  • Week 4: 5-3
                    • Week 5: 5-1
                      • Week 6: 4-2
                        • Week 7: 5-3
                          • Week 8: 7-2
                            • Week 9: 5-2

                              • Overall record: 80-15

                              about the writer

                              about the writer

                              Randy Johnson

                              College football reporter

                              Randy Johnson covers University of Minnesota football and college football for the Minnesota Star Tribune, along with Gophers hockey and the Wild.

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