Roger Tsien, 64, a University of California, San Diego researcher who shared the 2008 Nobel Prize in chemistry for helping to find a more effective way to peer inside cells and organisms, died Aug. 24.
Tsien, a first-generation American who began to explore chemistry at age 8, was hailed for "illuminating" the study of such diseases as cancer and HIV. He teamed with fellow scientists Osamu Shimomura and Martin Chalfie to turn green fluorescent protein, or GFP, which is found in jellyfish, into a research tool.
Chancellor Pradeep Khosla recalled the collaboration: "Shimomura identified the crucial jellyfish protein and revealed that it glowed bright green under ultraviolet light. Chalfie showed how it could be used as a biological marker. Combining his deep skills in chemistry and biology, Tsien found ways to make GFP glow more brightly and consistently; then he created a full palette of fluorescent proteins that scientists could use to track different cellular processes at the same time."
Khosla added: "GFPs have become a fundamental fixture in life sciences labs around the world, allowing researchers to look into cells or whole animals, to watch molecules interact in real-time and ask questions once thought impossible."
Nobel laureate K. Barry Sharpless of the Scripps Research Institute said, "Rarely are the smartest people the most creative, too — but Roger was both."
Tsien was born in New York City on Feb. 1, 1952. His father, Hsue Chu, was an engineer. His mother, Yi Ying Li, was a nurse.
His early years weren't easy. Tsien wrote in his Nobel biography that the family "chose a new housing development in Livingston, N.J., but the developer refused to sell to us, saying that they could not permit Livingston to become a Chinatown, nor could they afford the likelihood that other customers would refuse to buy houses next to a Chinese family."
Dr. Joy Browne, 71, the syndicated radio and TV psychologist who dispensed advice and inspiration over the air for nearly four decades, died Aug. 27 in Manhattan. She was still hosting her daily three-hour radio program.