Adrian Peterson takes on a career-high workload with 37 carries

After beginning the season as an afterthought in New Orleans, Adrian Peterson showed he still has what it takes to be a workhorse just when the Arizona Cardinals needed it most.

Peterson carried a career-high 37 times for 159 yards to take pressure off backup quarterback Drew Stanton and lead the Cardinals to a 20-10 victory over the host San Francisco 49ers on Sunday.

"That's the mind-set I've always had since I came into the league," Peterson said. "I'm going to wear those guys down and see if they can do it for four quarters. That's something they have to question themselves when it comes to the fourth quarter and I'm still coming in there."

The former Vikings star had 10 more carries in his third game with Arizona (4-4) than he had his four weeks combined with the Saints. He posted the most carries ever for an NFL player in his 30s and topped the 100-yard mark for the second time since being acquired in a trade last month.

"That's why they call him All Day, AD, because he can tote it all day," Cardinals receiver Larry Fitzgerald said.

Peterson's running and Stanton's pair of first-half touchdown passes were enough to help Arizona bounce back from a 33-0 loss to the Rams before last week's bye.

The undermanned 49ers (0-9) extended the worst start in franchise history and have lost 23 of the past 24 games overall. Newly acquired quarterback of the future Jimmy Garoppolo was mostly a spectator as rookie C.J. Beathard got battered once again behind a patchwork line.

New Orleans 30, Tampa Bay 10: The Saints (6-2) extended their winning streak to six when Drew Brees went 22-for-27 for 263 yards and two TDs. Alvin Kamara scored on a 6-yard run and a 33-yard reception, thrilling the home crowd with a waving, tackle-slipping run after his short catch. The Buccaneers (2-6) lost their fifth in a row and were not just beaten but beaten up.

Indinapolis 20, Houston 14: T.Y. Hilton had 175 yards receiving with two TDs, Jacoby Brissett threw for 308 yards and the Colts (3-6) halted a three-game skid by beating the host Texans (3-5), who struggled without injured Deshaun Watson. Tom Savage couldn't move the offense for most of the game but threw a touchdown pass in the fourth quarter. The Texans had first-and-goal in the final minute, but Savage threw three incompletions and was sacked and fumbled on the game's final play.

Oakland 27, Miami 24: Derek Carr threw for 300 yards, Marshawn Lynch scored twice in his return from suspension and the Raiders (4-5) held off the host Dolphins (4-4). Carr went 21-for-30 with one touchdown, a 44-yarder to Johnny Holton, and one interception as Oakland won for only the second time since Week 2. Miami's Jay Cutler, back after missing one game because of cracked ribs, completed his first 16 passes and finished with 311 passing yards and three scores.

Jacksonville 23, Cincinnati 7: With A.J. Green and Jalen Ramsey ejected, Jaydon Mickens delivered the knockout blow by returning a punt 63 yards for a score as the Jaguars (5-3) won consecutive games for the first time in 13 months and won at home for the first time since December. Blake Bortles threw for 259 yards and a touchdown.