– Tom Brady lost yet another one of his trusted targets, and this time he also lost a game.

C.J. Anderson scored on a 48-yard run with 12 minutes, 32 seconds left in overtime, powering the Denver Broncos past the New England Patriots 30-24 on a snowy Sunday night.

Watching from the cozy indoors at field level was Peyton Manning as Brock Osweiler and the Broncos (10-2) overcame a 21-7 fourth-quarter deficit and handed the Patriots (11-1) their first loss since 2014.

"It didn't look good at times," Broncos coach Gary Kubiak said, "but we figured out a way to get it done."

Now, the Carolina Panthers (11-0) are the NFL's only remaining unbeaten team.

Osweiler threw a 3-yard touchdown pass to Bubba Caldwell with 1:09 left in regulation to put the Broncos up 24-21. But Brady, playing without star tight end Rob Gronkowski after he injured his right knee, needed only five plays to drive the Patriots 51 yards and into range for Stephen Gostkowski's 47-yard field goal that tied the score at the end of regulation.

New England won the coin toss and elected to receive, but thanks to a sack by Von Miller, Denver forced a three-and-out. Then, on third-and-1 from the New England 48, Anderson raced around the left sideline and into the north end zone.

Gronkowski injured his right knee with 2:49 left in regulation and was carted off. There was no immediate word on his status.

Anderson rushed for 113 yards and two TDs on 15 carries.

Overall, the Broncos ran for 179 yards, particularly impressive given their two-touchdown deficit for much of the first half and their 21-7 hole they found themselves in after Brady threw a 63-yard scoring pass to Brandon Bolden on the first play of the fourth quarter.

The Patriots managed only 39 yards on 16 carries, however.

Osweiler improved to 2-0 since taking over for Manning. He completed 23 of 42 passes for 270 yards with one TD and one interception. Brady also was 23 of 42 for 280 yards with three TDs and no interceptions. Both were sacked three times.

Brady's three TD tosses put him in a tie with Dan Marino for third on the career list. But with Manning sitting this one out in a walking cast on his left foot, the greatest quarterback rivalry was put on hold — perhaps forever.

Instead of a 17th meeting between the QB greats, it was Brady vs. Osweiler, which doesn't have the same Hall of Fame ring to it.

Star pass rusher DeMarcus Ware missed the game because of a bad back and Denver lost two more members of the league's top-ranked defense on one play in the first quarter. Pro Bowl safety T.J. Ward and nose tackle Sylvester Williams suffered ankle injuries on New England's first run when LeGarrette Blount managed 2 yards. Ward and Williams were in walking boots after the game.