The least productive start of Patrick Mahomes' career ended Kansas City's nine-year run of division titles and put another remarkable streak in jeopardy.
Jalen Hurts was even worse a night later for the Philadelphia Eagles, as the two starting quarterbacks from last season's Super Bowl combined for a week that had never before been seen in the NFL.
Mahomes threw three interceptions and no touchdowns in the Chiefs' 20-10 loss to Houston that dealt a major blow to their playoff hopes. Hurts threw four interceptions, lost a fumble and had no TDs in a 22-19 overtime loss to the Los Angeles Chargers.
It marked the first time that the two starting QBs from the previous season's Super Bowl each threw at least three interceptions and had no TD passes in the same week.
The 19.8 passer rating for Mahomes and 31.3 for Hurts are the two lowest this season among quarterbacks with at least 25 attempts in a game as neither looked close to the level they reached last season on their runs to the Super Bowl.
Mahomes' rating was the lowest for any Chiefs QB with at least 20 attempts since Matt Cassel had a 19.1 in the 2010 season finale against the Raiders. The 10 points were the fewest ever scored by Kansas City in a game started by Mahomes at Arrowhead Stadium.
The loss eliminated Kansas City from contention in the AFC West after nine straight titles and put their run of seven straight appearances in the AFC title game in jeopardy. The Patriots are the only other team with longer streaks, having won 11 straight division titles from 2009-19 and made eight straight AFC title games from 2011-18 with Tom Brady.
It also dropped Kansas City's chances of making the playoffs to 11%, according to the NFL NextGen Stats model. Barring a shocking turn of events, this could set up the first AFC championship game without either Mahomes or Brady at quarterback since the 2010 season.