AJ Brodeur scored 16 points as host Penn beat No. 17 Villanova 78-75 on Tuesday night at the Palestra, the Quakers' first victory over the Wildcats since 2002.
Penn fans stormed the court after Villanova's Phil Booth missed the tying three-point attempt.
The national champion Wildcats had won 25 consecutive games against its Big 5 rivals — Temple, St. Joseph's, La Salle and Penn — in the annual round-robin series between the Philadelphia schools.
"They call it the Big 5. But really it seems like the Big 1," Brodeur said. "Villanova is always coming out on top."
The Wildcats' previous Big 5 loss was to Temple 76-61 on Dec. 5, 2012.
Maryland 94, Loyola (Md.) 71: Anthony Cowan Jr. scored 23 points, and freshman Jalen Smith added a career-high 20 as the host Terrapins (9-2) routed the Greyhounds (4-7). After letting a 24-point advantage shrink to 64-54, Maryland went on a 19-0 run.