216

The Panthers’ 216 rushing yards were the most against the Vikings defense in 44 games. In the 2015 season opener, the 49ers ran for 230 yards against Minnesota.

6

Case Keenum took six sacks, nearly doubling his season total (nine) entering Sunday’s game. The Vikings offensive line lost left tackle Riley Reiff because of an ankle injury after already being down two starters.

3

The Vikings’ three turnovers (two interceptions, fumble) are the offense’s most since their last loss, Oct. 1 against Detroit. In its three losses, Minnesota has more than half (seven) of its 13 turnovers this season.